Combined antiretroviral therapy ushered an era of survivable HIV infection in which people living with HIV (PLH) conduct normal life activities and enjoy measurably extended lifespans.However, despite viral control, PLH often experience a variety of cognitive, emotional, and physical phenotypes that diminish their quality of life, including cogniti
The article reviews some development trends brought about by globalization, particularly, a growing tax evasion and tax avoidance, an expansion of illicit financial flows and the proliferation of a global criminal network.The author draws attention to some new phenomena, particularly, cosmopolitanization of some parts of national elites and a deepe
Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis.Arf controls Mdm2, which in turn regulates p53, but Arf and Mdm2 also have p53-independent functions that affect tumor development.Moreover, inhibition of oncogene-induced tumorigenesis relies on Arf and p53, but the requirements of Arf and p53 in tumor
Directing and concentrating structures are used mainly on water coursers with unstable channel and major sediment transport or in areas with major bank erosion.The main purpose of these structures is to redirect water flow from ACN the stressed and very often eroded bank to the centre of the channel or other parts of the channel, where the water fl
In this paper we discuss the problem on parametric and non parametric estimation of the distributions generated by the Marshall-Olkin copula.This copula comes from the Marshall-Olkin bivariate exponential distribution used in reliability analysis.We generalize this model by the copula and different marginal distributions to construct several bivari